diff --git a/pkgs/extrae/default.nix b/pkgs/extrae/default.nix
index 2ceec916..a6827076 100644
--- a/pkgs/extrae/default.nix
+++ b/pkgs/extrae/default.nix
@@ -20,6 +20,7 @@
 #, python3Packages
 , installShellFiles
 , symlinkJoin
+, enablePapi ? stdenv.hostPlatform == stdenv.buildPlatform # Disabled when cross-compiling
 }:
 
 let
@@ -87,7 +88,7 @@ stdenv.mkDerivation rec {
       --enable-sampling
       --with-unwind=${libunwind.dev}
       --with-xml-prefix=${libxml2.dev}
-      --with-papi=${papi}
+      ${lib.optionalString enablePapi "--with-papi=${papi}"}
       ${if (mpi != null) then ''--with-mpi=${mpi}''
         else ''--without-mpi''}
       --without-dyninst)
diff --git a/pkgs/nanos6/default.nix b/pkgs/nanos6/default.nix
index 64ee2888..c419f2d9 100644
--- a/pkgs/nanos6/default.nix
+++ b/pkgs/nanos6/default.nix
@@ -16,6 +16,7 @@
 , jemallocNanos6 ? null
 , cachelineBytes ? 64
 , enableGlibcxxDebug ? false
+, enablePapi ? stdenv.hostPlatform == stdenv.buildPlatform # Disabled when cross-compiling
 , useGit ? false
 , gitUrl ? "ssh://git@bscpm04.bsc.es/nanos6/nanos6"
 , gitBranch ? "master"
@@ -97,16 +98,14 @@ in
       # TODO: papi_version is needed for configure:
       # ./configure: line 27378: papi_version: command not found
       # This probably breaks cross-compilation
-      papi
-    ];
+    ] ++ lib.optionals enablePapi [ papi ];
 
     buildInputs = [
       boost
       numactl
       hwloc
-      papi
       ovni
-    ];
+    ] ++ lib.optionals enablePapi [ papi ];
 
     # Create a script that sets NANOS6_HOME
     postInstall = ''
diff --git a/pkgs/nosv/default.nix b/pkgs/nosv/default.nix
index 0c02fc99..1b33e03d 100644
--- a/pkgs/nosv/default.nix
+++ b/pkgs/nosv/default.nix
@@ -7,7 +7,7 @@
 , numactl
 , hwloc
 , papi
-, enablePapi ? true
+, enablePapi ? stdenv.hostPlatform == stdenv.buildPlatform # Disabled when cross-compiling
 , cacheline ? 64 # bits
 , ovni ? null
 , useGit ? false